By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic learn on osteoarthritis has been performed in most cases from the his tological and biochemical points of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical tension has been proven to be the vital think about the initiation of osteoarthritis. even though the precise approach in which mechanical tension ends up in the entire destruction of cartilage tissue is still uncertain, numerous new study tools have enabled us to achieve a deeper knowing of the method of degeneration. In October 1997, we geared up a global symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most subject matters being up-to-date re seek, analysis, and remedy of osteoarthritis. The lawsuits of the symposium are provided the following in 5 sections: (1) Mechanical rigidity and reactions of chondrocytes, corresponding to intracellular ion adjustments, adjustments within the cytoskeleton, intracellular messenger platforms, liberate of gasoline mediators, and alterations in electromechanical homes of cartilage; (2) sensible prognosis of osteoarthritis by way of MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) remedy with a promising uncomplicated washout procedure and IL-1RA and MMP antagonists; (4) Cartilage fix by way of new grafting tech niques; and (5) difficulties following overall joint alternative. We basically desire that the complicated wisdom supplied during this quantity of lawsuits should be useful to our readers.
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Extra resources for Advances in Osteoarthritis
Effect of cyclic tensile stretch on DNA synthesis in bovine articular chondrocytes. Cells were seeded at a density of 5 X 104 cells/ml in specially built, flexible-bottom culture plates. DNA synthesis was measured based on [3HJthymidine incorporation. Data are expressed as the mean ± SD of 6 wells. 0; 4 c:>. r:: 0- Vl c: ell U >. Qj u """'E 3 00 Co 2 .... 0 v '0 e 0- 0 Control PDB U I nM PDBU 100M PDBU 1000M FIG. 4. Effect of phorbol ester on proteoglycan synthesis. Cells were seeded at a density of 2 X 105 cells/ml in 96-well plates.
A slight increase observed in the relative length of GAG chains could explain this finding. Another explanation could be a higher substitution of the core protein serine residues with GAG chains, as in rat chondrosarcoma only 55% of the serine residues were substituted with carbohydrate . High hydrostatic pressure had profound effects on the structural organization of microfilaments and microtubules in chondrocytes [48,55]. Along with the depolymerization of microtubules, high pressure caused a packed pattern of the Golgi apparatus close to the cell nucleus .
Lee RC, Rich JB, Kelley KM, et al (1982) A comparison of in vitro cellular responses to mechanical and electrical stimulation. Am Surg 48:567-574 29. de Witt MT, Handley CJ, Oakes BW, et al (1984) In vitro response of chondrocytes to mechanical loading. The effect of short term mechanical tension. Connect Tissue Res 12:97-109 30. Uchida A, Yamashita K, Hashimoto K, et al (1988) The effect of mechanical stress on cultured growth cartilage cells. Connect Tissue Res 17:305-311 31. Parkkinen JJ, Lammi MJ, Tammi MI, et al (1994) Proteoglycan synthesis and cytoskeleton in hydrostatically loaded chondrocytes.
Advances in Osteoarthritis by Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)