By Robert B. McComb
There could be without doubt that alkaline phosphatase is among the so much greatly in vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the benefit and sensitivity with which its task might be measured. regrettably, those wide-ranging yet usually superficial experimental experiences were up by way of in depth and systematic investigations in just a couple of constrained parts of the biochemistry and chemical pathology of alkaline phosphatase. the end result has been the buildup of a systematic literature of intimidating proportions, and the inevitable rediscovery of already recognized proof in regards to the enzyme. Scientists are taught early of their careers that, within the phrases of Sir John Herschel, "Hasty generalization is the bane of technological know-how. " however, moments arrive in all spheres of medical job whilst generalization turns into crucial, to codify and to choose between the mass of information already amassed, and to supply beginning issues for brand new advancements and new traces of research. this is often very true in a box similar to alkaline phosphatase study, during which very actual hazards exist that the seeds of primary knowing should be misplaced amidst an unexamined harvest of empirical observations. The historical past of the learn of alkaline phosphatase presents numerous circumstances whilst beneficial generalizations have emerged. sometimes, the conclusions drawn at the foundation of obtainable proof have been flawed; extra often, they've got stood the try of additional experimentation, and continually, they've got supplied new insights into the character and correct ties of this enzyme.
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Extra info for Alkaline Phosphatase
6. 1. Species Several fungi synthesize alkaline phosphatase. These include various molds and yeasts,58-71 such as Neurospora crassa,63-65 Aspergillus nidulans,66 Saccharomyces cerevisiae,61 Candida albicans,67 and Coprinus lagopus. 68 One strain each of A. oryzae andA. niger failed to produce alkaline phosphatase under stated conditions of culture. 2. Enzyme Induction and Repression A growth medium with high inorganic phosphate content tends to diminish alkaline phosphatase production by fungi,64,66,68 whereas a low phosphate content enhances the synthesis of the enzyme.
Fluorescens Pseudomonas spp. Salmonella typhimurium Serratia marcescens Serratia spp. Staphylococcus aureus Thermus aquaticus Thiobacillus thioparus Vibrio alginoly ticus 152 150 153 154 44 155,156 157,158 150 143, 159-161 136 1003 162 influenced by the method of fIxation and other cytochemical procedural details. Thus, glutaraldehyde-flXed E. 48 In Pseudomonas aernginosa, glutaraldehyde fIxation caused the enzyme to appear on the cell surface. 52 Wetzel et al. 48 showed that alkaline phosphatase activity in E.
137. Jenner, H. , and Kay, H. , The phosphatases of mammalian tissues. III. Magnesium and the phosphatase system,1. Bioi. , 93, 733,1931. 138. Pett, L. , and Wynne, A. , The influence of arsenate and arsenite on the enzyme breakdown of phosphoric acid esters, Biochem. , 28, 365, 1934. 139. Du Bois, K. , Cochran, K. , Inhibition of phosphatases by beryllium and antagonism of the inhibition by manganese, Science, 11 0,420, 1949. 140. Fishman, W. , Organ-specific behavior exhibited by rat intestine and liver alkaline phosphatase, Biochirn.
Alkaline Phosphatase by Robert B. McComb