Richard F. Lockey, Dennis K. Ledford's Allergens and Allergen Immunotherapy PDF

By Richard F. Lockey, Dennis K. Ledford

ISBN-10: 1842145738

ISBN-13: 9781842145739

ISBN-10: 1842145746

ISBN-13: 9781842145746

This 5th version of the bestselling Allergens and Allergen Immunotherapy is now thoroughly up-to-date and revised to incorporate subcutaneous, sublingual, and oral immunomodulator remedies of allergic disease.

The redesigned publication keeps to supply accomplished assurance of all kinds of allergens and allergen vaccines, giving clinicians the basic info they should thoroughly make a analysis and provide the absolute best remedies.

The 5th variation comprises many new and revised chapters―particularly within the fields of pores and skin testing―and wide updates to the sublingual and oral immunotherapy chapters.

Key positive aspects:

  • Comprehensive – covers an enormous variety of allergens and allergen immunotherapies, supplying all of the beneficial info in a single volume
  • Synoptic – provides the fundamental details utilizing figures and tables for immediate entry
  • Up-to-date – comprises the very most up-to-date details on subcutaneous, sublingual and oral allergen immunotherapies to supply the absolute best treatments
  • Reliable – offers uncomplicated info that each one clinicians want to know approximately cross-reactivity between allergens and the way it impacts analysis and therapy, in addition to the main details essential to perform any kind of immunotherapy in a secure and potent demeanour
  • Supplemental varieties – comprises template varieties that may be utilized by the clinician in day-by-day practice

The 5th version of this vintage textual content is still a vital touchstone for any practitioner who conducts epidermis exams and prescribes subcutaneous, sublingual, and oral immunotherapies.

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Extra resources for Allergens and Allergen Immunotherapy

Sample text

Development of techniques for extraction of allergens: availability of expanded testing and treatment reagents made available [39,40]. Oral tolerance to plant oil-soluble fraction agent of contact dermatitis: derivative modification of Native American preventive practice of chewing “poison ivy” shoots [134,137]. Differentiation between antibodies involved in states of hypersensitiveness and desensitization: anaphylactic antibody, precipitin, and atopic regain [194]. “Desensitization” by the procedure of Besredka in an anaphylactic animal model not attainable in human hypersensitiveness objective of hyposensitization [70].

Urbach attempted to bypass distressing gastrointestinal symptoms following ingestion of pollen vaccines by advocating oral administration of specific pollen digest peptones (propetan) [155]. Since collection of pollen supplies was difficult, Urbach prepared peptone derivatives of blossoms of trees, grasses, and grass seeds for use as orally administered allergens [156]. Passive transfer experiments by Bernstein and Feinberg calculated that more than a pound of raw pollen would be required orally to reach a circulating antigen concentration obtained by injection of maximally tolerated doses of pollen vaccine [157].

For many subsequent ­centuries, the technique of gaining tolerance or active immunity through incremental dosage schedules continued to be known as mithradatising. The renowned Greek physician Claudius Galen ­(130–200 ad), who practiced in Rome, had noted that snake venoms taken by mouth were devoid of the systemic toxic actions effected by snake bites [129]. According to folklore, this knowledge allowed snake charmers of the classic GrecoRoman era to acquire protection against potentially fatal bites by drinking from serpent-infested water that contained traces of their venoms [130]—a less traumatic method than seeking protection through self-inflicted bites.

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Allergens and Allergen Immunotherapy by Richard F. Lockey, Dennis K. Ledford


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