By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play a tremendous position in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step approach: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated through numerous varied hormones. The sodium channels additionally play an important position in a couple of disorder states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful variety presents the 1st in-depth trade of principles bearing on those sodium channels, their rules and involvement in general and pathophysiological occasions. Key good points * Summarizes present nation of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal legislation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents rules on sodium channels and illness
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Extra resources for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
Fuller, C. , Bradford, A. , Lifton, R. , Warnock, D. , Bubien, J. , and Benos, D. J. (1996a). Peptide block of constitutively activated Na+ channels in Liddle's disease. Am. J. Physiol. 270, C214-C223. Ismailov, I. , Berdiev, B. , Bradford, A. , Awayda, M. , Fuller, C. , and Benos, D. J. (1996b). Associated proteins and renal epithelial Na' channel function. J. Membr. Biol. 149,123-132. Ismailov, I. , Awayda, M. , Berdiev, B. , Bubien, J. , Lucas, J. , Fuller, C. , and Benos, D. J. Triple barrel organization of ENaC, a cloned epithelial Na' channel subunit.
W. (1990). Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250, 568-571. CHAPTER 2 Membrane Topology,Subunit Composition, and Stoichiometry of the Epithelial NaS Channel Peter M. Snyder,” Chun Cheng,? and Michael J. Welsh? Departments of Internal Medicine and Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242 I. Introduction 11. Topology of ENaC 111. Subunit Composition of hENaC IV.
Fuller et al. 5 ng Day2 Day1 Day2 Day2 RECORDING: FIGURE 2 Amiloride-sensitive currents in oocytes injected with a combination of abENaC and fl and yrENaC. A greater amiloride-sensitive current was observed in oocytes expressing all three subunits than in those expressing abENaC alone. 5 ng of each cRNA exhibited a fivefold increase in current following 48 h of expression. Results are 2SEM. Reprinted with permission from Fuller e l al. 1995. was expressed in oocytes. Intracellular PKA consensus sequences have been identified only in the y subunits of the rat and Xenopus isoforms; the human ENaC has no predicted PKA-sensitive sites (Garty and Palmer, 1997).
Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity by Dale J. Benos (Eds.)