Read e-book online Amiloride-Sensitive Sodium Channels: Physiology and PDF

By Dale J. Benos (Eds.)

ISBN-10: 0080585183

ISBN-13: 9780080585185

ISBN-10: 0120890305

ISBN-13: 9780120890309

ISBN-10: 0121533476

ISBN-13: 9780121533472

Sodium reabsorbing epithelia play a tremendous position in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step approach: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated through numerous varied hormones. The sodium channels additionally play an important position in a couple of disorder states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful variety presents the 1st in-depth trade of principles bearing on those sodium channels, their rules and involvement in general and pathophysiological occasions. Key good points * Summarizes present nation of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal legislation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents rules on sodium channels and illness

Show description

Read or Download Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity PDF

Similar basic sciences books

Download e-book for kindle: Basic Virology, 3rd Edition by Martinez J. Hewlett, David C. Bloom, David Camerini Edward

Perfect for the scholar looking a great knowing of the elemental rules during this speedily constructing box, this best-selling textual content deals a complete advent to the basics of virology. that includes an improved paintings software now in full-color, the hot version has been up-to-date all through. new version accommodates extra studying feedback, improved evaluation questions, bankruptcy outlines and full-colour paintings includes new chapters facing viruses and melanoma, iteration and use of recombinant viruses and virus-like debris, viral evolution, community biology and viruses, and animal versions and transgenics, in addition to a bankruptcy dedicated to HIV and AIDS Downloadable art, unique animations and on-line assets can be found at www.

Embryology by Ronald W Dudek; James D Fix PDF

Global struggle II Troop kind Parachutes used to be written for somebody drawn to the heritage of airborne troops, and is profusely illustrated with unpublished interval and modern images. creditors, modelers and researchers can be capable of establish all the troop parachutes utilized by the Allied powers in global struggle II.

Robert J. Alpern, Michael J. Caplan, Orson W. Moe's Seldin and Giebisch's The Kidney, Fifth Edition: Physiology PDF

A vintage nephrology reference for over 25years, Seldin & Giebisch's The Kidney, is the stated authority on renal body structure and pathophysiology. during this fifth version, such new and strong disciplines as genetics and telephone biology were deployed to deepen and widen additional the explanatory framework.

Download e-book for kindle: On the Texture of Brains: An Introduction to Neuroanatomy by Valentino Braitenberg

I think that the main interesting factor on the earth, be­ facets the realm itself, is the human mind. furthermore, i'm convinced coherent common philosophy will in simple terms be attainable after we have understood how the mind, itself an item of physics, generates the outline of the actual be aware. consequently a publication at the mind, be it the fly's or the mouse's mind, wishes no justification.

Extra resources for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

Sample text

Fuller, C. , Bradford, A. , Lifton, R. , Warnock, D. , Bubien, J. , and Benos, D. J. (1996a). Peptide block of constitutively activated Na+ channels in Liddle's disease. Am. J. Physiol. 270, C214-C223. Ismailov, I. , Berdiev, B. , Bradford, A. , Awayda, M. , Fuller, C. , and Benos, D. J. (1996b). Associated proteins and renal epithelial Na' channel function. J. Membr. Biol. 149,123-132. Ismailov, I. , Awayda, M. , Berdiev, B. , Bubien, J. , Lucas, J. , Fuller, C. , and Benos, D. J. Triple barrel organization of ENaC, a cloned epithelial Na' channel subunit.

W. (1990). Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250, 568-571. CHAPTER 2 Membrane Topology,Subunit Composition, and Stoichiometry of the Epithelial NaS Channel Peter M. Snyder,” Chun Cheng,? and Michael J. Welsh? Departments of Internal Medicine and Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242 I. Introduction 11. Topology of ENaC 111. Subunit Composition of hENaC IV.

Fuller et al. 5 ng Day2 Day1 Day2 Day2 RECORDING: FIGURE 2 Amiloride-sensitive currents in oocytes injected with a combination of abENaC and fl and yrENaC. A greater amiloride-sensitive current was observed in oocytes expressing all three subunits than in those expressing abENaC alone. 5 ng of each cRNA exhibited a fivefold increase in current following 48 h of expression. Results are 2SEM. Reprinted with permission from Fuller e l al. 1995. was expressed in oocytes. Intracellular PKA consensus sequences have been identified only in the y subunits of the rat and Xenopus isoforms; the human ENaC has no predicted PKA-sensitive sites (Garty and Palmer, 1997).

Download PDF sample

Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity by Dale J. Benos (Eds.)


by William
4.4

Rated 4.30 of 5 – based on 19 votes