Download PDF by J.-P. Montani, B. N. Van Vliet (auth.), Professor Thomas: Angiotensin Vol. I

By J.-P. Montani, B. N. Van Vliet (auth.), Professor Thomas Unger, Professor Bernward A. Schölkens (eds.)

ISBN-10: 3540406409

ISBN-13: 9783540406402

ISBN-10: 3540406417

ISBN-13: 9783540406419

ISBN-10: 3642184952

ISBN-13: 9783642184956

Nearly thirty years in the past, in 1974, the quantity on Angiotensin edited through Irvine H.Page and F. Merlin Bumpus increased the guide of Experimental Pharmacology. Even after twenty years the multiplicity of its activities appears to be like to not were absolutely came upon. to name recognition to its many services is among the reasons of this e-book. This re-creation of the amount on Angiotensin makes an attempt to supply an up-to-date account of the data and findings collected because the complexity of angiotensin used to be so adequately recognized.

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Example text

Regulation of the Renin-Angiotensin System During Development. . . 4 Integration of Phylogeny and Ontogeny. . . Phylogeny and Ontogeny. . . . . . . Biochemistry of the Renin-Angiotensin System. Function and Regulation . . . . . . . Perspectives . . . . . . . . . . .. .. , 56 56 57 58 59 References . . . . . . . . . . . . . . . . . . . . 61 . . . . . . . . . . . . . . . . . . . . . . . . . .

1969; Nishimura et al. 1973, 1980). Avian kidneys possess macula densa cells that have some characteristics of a mammalian macula densa (Sokabe et al. 1969). Therefore, the JG apparatus in birds represents a transitional JG apparatus between the primitive and mammalian types. It therefore appears that the vascular component of the JG apparatus evolved phylogeneti- 36 H. Nishimura cally earlier than the macula dens a, the tubular component. This is important when we consider the function of the RAS in nonmammalian vertebrates.

1973) or from tyrosine (snake Ang 1) (Nakayama et al. 1977) to histidine (turtle and mammalian Ang I) requires a one-point mutation of the triplet sequence of the DNA code (Takei et al. 1993b), whereas a two-nucleotide difference exists between alanine and tyrosine (or histidine) (Takei et al. 1993b) and between serine (avian Ang 1) and histidine. This structural difference in Ang I agrees with the notion that the evolutionary line leading to the mammals departed from the reptilian-avian line at a very early stage of tetrapod evolution and that the crocodilians are phylogenetically closer to avians.

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Angiotensin Vol. I by J.-P. Montani, B. N. Van Vliet (auth.), Professor Thomas Unger, Professor Bernward A. Schölkens (eds.)


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