New PDF release: Animal Models and Hypoxia. Proceedings of an International

By V. Stefanovich

ISBN-10: 0080259111

ISBN-13: 9780080259116

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Additional resources for Animal Models and Hypoxia. Proceedings of an International Symposium on Animal Models and Hypoxia, Held at Wiesbaden, Federal Republic of Germany, 19 November 1979

Sample text

The therapeutic effect was evaluated by estimating ischemic brain edema and by comparing blood flow 2 hours after the onset of ischemia with the flow rate immediately after vascular occlusion. Every animal, in consequence, served as its own control. The results obtained so far are depressingly negative. Neither a decrease of vascular tone by sympathectomy or prostacyclin, a decrease of blood viscosity by defibrinogenation, or hemodilution, or metabolic inhibition by barbiturate or hypothermia caused a significant improvement of blood flow or an amelioration of ischemic brain edema.

CP ATP ADP AMP High energy phosphates in the isolated rat brain. After a perfusion period of 30 min (control) the flou to the brain uas interrupted for 1 min (ischemia), thereafter perfusion uas continued for 2 min (recovery). D. for control values). Different from controT: P < 0 . 0 5 P < 0 . 0 1 . Different from the corresponding value obtained uithout methohexital: * P < 0 . 0 5 , * * P < 0 . 0 1 . X X X J. Krieglstein, Β. Dirks and J. 99 Gly Fig. G GP FDp' Lac FP Pyr 7. Lac/Pyr=2126 * τ—ι—ι—ι—ι—ι—r Gly G GP FDP Lac FP Pyr Substrates of glycolysis in the isolated rat brain.

Cerebral blood flow and the cerebral metabolic rate of oxygen increased markedly after amphetamine application and in immobilization stress, as could be demonstrated by Carlsson,* Hagerdal and Siesjo (1975 a and 1975 b) . The EEG changes after the application of either metamphetamine (9 mg/kg body weight i. ) or 2,4-dinitrophenol (20 mg/kg body weight i. ) were similar. Both substances produce an activation of amplitude and frequency which is reversible 90 to 120 minutes after the application (Fig.

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Animal Models and Hypoxia. Proceedings of an International Symposium on Animal Models and Hypoxia, Held at Wiesbaden, Federal Republic of Germany, 19 November 1979 by V. Stefanovich


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