New PDF release: Antimicrobial drug discovery : emerging strategies

By George Tegos, Eleftherios Mylonakis

ISBN-10: 1845939433

ISBN-13: 9781845939434

Drug resistance is expanding between quite a few human pathogenic microorganisms comparable to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as the most vital medical demanding situations of this century. elevated normal wisdom and worry of those pathogens potential there's a growing to be call for for study to take on the specter of multidrug resistance. Documenting the most recent study within the box, this booklet discusses present and promising actions to find new antimicrobials in 5 key components: molecular genetics and structures microbiology; artificial, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and light-weight- and nano-based applied sciences.

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Science 319, 1391–1394. Loeffler, J. A. (2003) Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillinsensitive and -resistant Streptococcus pneumoniae strains. Antimicrobial Agents and Chemotherapy 47, 375–377. , Djurkovic, S. A. (2003) Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia. Infection and Immunity 71, 6199–6204. Lomovskaya, O. A. (2006) Practical applications and feasibility of efflux pump inhibitors in the clinic – a vision for applied use.

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2011) Anti-infective therapeutics from the lepidopteran model host Galleria mellonella. Current Pharmaceutical Design 17, 1240–1245. Vollmer, W. (2008) Targeting the bacterial Z-ring. Chemistry and Biology 2, 93–94. E. J. (2009) Is drug release necessary for Emerging Discovery Strategies antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamineantibiotic conjugates. Biometals 22, 633–648.

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Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis

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