By A. G. Herman (auth.), Arnold G. Herman (eds.)
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Additional info for Antithrombotics: Pathophysiological Rationale for Pharmacological Interventions
M_CoI,'_I .. 3. Pharmacological effects of L-Arg and L-NMMA on aggregation of human washed platelets. Platelets were isolated from blood using prostacyclin (159), labelled with aequorin (160) and aggregation (upper panel) and [Ca 2 +il (lower panel) were monitored in a Chronolog platelet ionized calcium aggregometer. Collagen (1 llg/ml) - induced platelet aggregation resulted in a maximal increase in light transmission and [ca 2 +i 1 (A). These effects were inhibited by L- Arg (10 and 30 pM) (B and C).
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Antithrombotics: Pathophysiological Rationale for Pharmacological Interventions by A. G. Herman (auth.), Arnold G. Herman (eds.)