Antithrombotics: Pathophysiological Rationale for - download pdf or read online

By A. G. Herman (auth.), Arnold G. Herman (eds.)

ISBN-10: 9401055408

ISBN-13: 9789401055406

ISBN-10: 9401134847

ISBN-13: 9789401134842

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M_CoI,'_I .. 3. Pharmacological effects of L-Arg and L-NMMA on aggregation of human washed platelets. Platelets were isolated from blood using prostacyclin (159), labelled with aequorin (160) and aggregation (upper panel) and [Ca 2 +il (lower panel) were monitored in a Chronolog platelet ionized calcium aggregometer. Collagen (1 llg/ml) - induced platelet aggregation resulted in a maximal increase in light transmission and [ca 2 +i 1 (A). These effects were inhibited by L- Arg (10 and 30 pM) (B and C).

Res. 60,169-176. 91. R. (1989) Endotheliumderived vasoactive substances: Potential role in hypertension, atherosclerosis, and vascular occlusion. J. Cardiovasc. Pharmacol. 14,S63-S69. 92. P. (1991) The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit. Br. J. Pharmacol. 102,759-763. 93. , Pytel, B. NG-monomethylL-arginine increases platelet deposition on damaged endothelium in vivo. A scanning electron microscopy study, in preparation.

H. (1989) , Platelet inhibitor agents in cardiovascular disease an update', J. Am. ColI. Cardiol. 14, 813-836. 40. VERSTRAETE, M. (1990) 'Les anti-aggregants en 1990', La Revue de Med. Int. 11, 209-215. 41. S. C. (1988) 'Antiplatelet agents in the secondary prevention of stroke', Stroke 19, 436-442. 42. , HELD, P. and MCMAHON, S. (1990) 'Routine medical management of acute myocardial infarction. Lessons from overvieuws of recent randomi zed controlled trials', Circulation 82 (suppl II), II117-II134.

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Antithrombotics: Pathophysiological Rationale for Pharmacological Interventions by A. G. Herman (auth.), Arnold G. Herman (eds.)


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