By Hilary Koprowski (auth.), Jacob A. Brody M.D., Professor Dr. Werner Henle, Hilary Koprowski M.D. (eds.)
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Additional resources for Chronic Infectious Neuropathic Agents (CHINA) and other Slow Virus Infections
Arch. ges. Virusforsch. 10, 501-509 (1960). An electron microscope study of tissue cultures infected with visna virus. Virology 14, 463-475 (1961). The growth cycle of visna virus in monolayer cultures of sheep cells. Virology 19, 273-278 (1963 a). Neutralization of visna virus by antisera from sheep. ]. Immunol. 90, 185-192 (1963b). - A comparison of visna and maedi viruses. I. Physical, chemical and biological properties. Res. Vet. Sci. 6, 117-129 (1965 a). - Effect of 5-bromodeoxyuridine and actinomycin D on the growth of visna virus in cell cultures.
C. c. e. p. e. p. e. p. e. 1 35 17 40 20 M/4 30 * Brain of ninth passage in goats of Compton strain. Estimate 0/ size by filtration It was of interest to determine the size of the scrapie virus particle inasmuch as such information in the literature was at best speculative. l diameters. Serial dilutions of filtrates were inoculated intracerebrally into litters of three-to five-day-old Swiss mice. l membrane. l. In support of these results are data, obtained by ALPER et al. for inactivation of scrapie by ionizing radiation.
The "release time" of visna virus was estimated by the method of RUBIN and coworkers (1955) to be approximately 2 hours. Almost 99 % of the CAY was neutralized by visna antiserum applied to the intact cell layer indicating that most of the virus was located at the cell membrane (THoRMAR, 1963 a). It would appear, Fig. 4. A section of infected cells showing budding of the cell membrane, double-walled spherical bodies, and visna virus particles with a central core. OS04 fixation and lead hydroxide staining.
Chronic Infectious Neuropathic Agents (CHINA) and other Slow Virus Infections by Hilary Koprowski (auth.), Jacob A. Brody M.D., Professor Dr. Werner Henle, Hilary Koprowski M.D. (eds.)