By Robert J. Alpern, Michael J. Caplan, Orson W. Moe
A vintage nephrology reference for over 25years, Seldin & Giebisch's The Kidney, is the stated authority on renal body structure and pathophysiology. during this fifth version, such new and robust disciplines as genetics and telephone biology were deployed to deepen and widen extra the explanatory framework. not just have prior chapters been greatly up-to-date, yet new chapters were further to include extra disciplines. person chapters, for instance, now offer distinct therapy of the importance of cilia; the function of stem cells is now given certain attention. eventually, there was an important enlargement of the element of pathophysiology, incorporating the more recent findings of mobile biology and genetics. in case you examine the advance of ordinary renal functionality or the mechanisms underlying renal illness, Seldin & Giebisch's The Kidney is your no 1 resource for information.Offers the main accomplished insurance out there of fluid and electrolyte law and dysregulation in 85 thoroughly revised chapters and 10 new chapters.Includes 4sections, 62 chapters, dedicated to law and problems of acid-base homeostasis, and epithelial and nonepithelial shipping regulation. Includes foreword by Donald Seldin and Gerhard Giebisch, global well known names in nephrology and editors of the former 3 variations.
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A vintage nephrology reference for over 25years, Seldin & Giebisch's The Kidney, is the said authority on renal body structure and pathophysiology. during this fifth version, such new and robust disciplines as genetics and cellphone biology were deployed to deepen and widen additional the explanatory framework.
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Additional resources for Seldin and Giebisch's The Kidney, Fifth Edition: Physiology & Pathophysiology
Simultaneous knockout of plastin-1, villin, and espin produces animals whose brush borders are short, and characterized by reduced numbers of disorganized actin filaments and mislocalized myosin. 97 Several other polypeptides, associated with the microvillus core and the terminal web, have also been identified. 98 The C-terminal tails of these polypeptides bind to actin filaments, while their N-termini interact with proteins in the membrane. A number of proteins involved in the generation or regulation of intracellular second messengers associate in macromolecular complexes with ezrinÀradixinÀmoesin family members, suggesting that in addition to functioning as linkers these proteins may also act as scaffolding for the assembly of components involved in signal transduction.
These lines are of particular interest because of the proclivity of the proximal tubule to suffer injury following ischemic insult. 169,170 Cultures of cell lines derived in this fashion are not, however, always able to stably maintain the uniform morphology of a simple epithelium, limiting their usefulness for studies of epithelial polarity. More promising results have been obtained using cell lines derived from mice constitutively expressing immortalization factors as transgenes. 167,168 While certainly not perfect, this line does grow as a simple epithelium, and has the added advantage of providing an in vitro correlate to in vivo mouse experiments.
It is not known whether these calcium-dependent activities of villin are manifest in vivo. If villin does indeed sever or shorten actin filaments within the living cell, it would seem likely that perturbations which produce elevations of intracellular calcium concentrations may lead to structurally significant alterations in the organization of the microvillar scaffolding. During embryonic development, villin is expressed throughout I. EPITHELIAL AND NONEPITHELIAL TRANSPORT AND REGULATION 10 1.
Seldin and Giebisch's The Kidney, Fifth Edition: Physiology & Pathophysiology by Robert J. Alpern, Michael J. Caplan, Orson W. Moe